NFL Week 16 Predictions & Tips

  • The Steelers, Texans, and Vikings enter Week 16 with playoff spots in the bag.

  • With another win, the Chiefs have moved to the top of the overall standings with a 13-1 record.

  • Hailed as a potential Super Bowl preview, the Bills edged the Lions 48-42 last week.


Many teams may have now secured their places in the postseason, but each is clearly still keen to finish their 17 games on a high and carry momentum into the playoffs. 

The Kansas City Chiefs clocked yet another win, the Buffalo Bills went all-out, as did the Detroit Lions, in their 48-42 game, and both the Philadelphia Eagles and Minnesota Vikings continue to obliterate all in their way.

Now deep in the month of December, the elements are playing an increasingly prominent role, so while these are the Week 16 NFL picks, it’s always worth looking to the live betting when the weather turns.

Detroit Lions at Chicago Bears

It was a loss, the first in a very long time, but the Detroit Lions can take solace in going toe-to-toe with the Bills and coming away with only a one-score loss at 48-42. 

Coach Dan Campbell says there’re positives to draw from losing, like the team getting grounded again, needing to dig deep to appreciate the position they’re in. So, even with a couple more big injuries, expect them to fight back.

For the Chicago Bears, the flying Minnesota Vikings dealt them their eighth successive loss, this time to the tune of a 30-12 scoreline on the road. 

On offence, the Vikings were rather tame: it was the defence that ruled the day.

Caleb Williams was under pressure early and often, ending bruised and exhausted having taken a couple of big, clean hits.

Now, the Bears face a strong Lions defence and an offence that looks primed to make a point. So, the Week 16 picks from the NFL betting for this one go to the Lions to beat the -6.5 spread and the game to see over 48 total points.

Cleveland Browns at Cincinnati Bengals

For now, the Cincinnati Bengals remain in playoff contention, having defeated the Tennessee Titans 37-27 last week, but it’d be tough to call it an overly convincing win. 

The defence did a lot of the heavy lifting, ending the day with a sack, four interceptions, two fumble recoveries, and a touchdown, while Joe Burrow threw two interceptions and three touchdowns. 

The Cleveland Browns look primed to continue their downward slide with yet another change at quarterback. While Jameis Winston did oversee Cleveland’s highest-scoring spell this season, he just couldn’t resist the picks. 

In the last three games, Winston threw eight interceptions and oversaw three losses.

Now, the ball will go to Dorian Thompson-Robinson, who has amassed three interceptions from four appearances this year.

With a rip-roaring defence on a high and an offence that can put up big scores even on off days against lowly teams, the NFL picks for this Week 16 clash side with the Bengals at -7.5 on the spread. 

Minnesota Vikings at Seattle Seahawks

Sam Darnold has emerged as a legitimate MVP contender this season – especially if you go by the ever-louder chants at the U.S. Bank Stadium. That said, his 231 yards for a touchdown and a pick weren’t great last week. 

It didn’t stop the Vikings from powering to seven wins on the bounce, tied with the Lions at 12-2 atop the NFC North, and both Aaron Jones and Cam Akers surging into the end zone. 

Also now tied for the top spot of their division, the Seattle Seahawks couldn’t press their advantage at home against the Green Bay Packers, eventually walking off as the 30-13 losers and without Geno Smith.

Early reports indicate that Smith’s suspected knee or ankle injury isn’t too serious, but even if the quarterback does suit up against the Vikings, he’ll be sore, and the Minnesota defence just bullied Williams to secure a win.

While the Vikings have lost their last five trips to Seattle, this is a very different team to even the one that travelled in 2020 – their last meeting on the west coast. 

The Vikings are rolling, the defence is hungry, and they’ve held up well on the road this season (5-1-0), leading the NFL picks for this Week 16 game to point towards Minnesota at -3 on the spread.


NFL Tips & Predictions

888Sport’s team of sports betting experts are here throughout the 2024 NFL season to provide their best NFL tips and predictions.

Straight up, against the spread and points total wagers will be tipped for those looking to bet on NFL games from the opening weekend of the season in September through to the Super Bowl in late winter.

Our NFL tips cover a plethora of gambling options for punters to evaluate. If the point spread or team totals aren’t to your liking, you can dive into player props and numerous other markets to find the value you’re after. 

The experience and knowhow of our experts is invaluable whether you’re looking into preseason Super Bowl tips, the NFL Draft or trying to identify the season’s betting trends.

Free NFL Tips

All of our writers have covered the league for years, and closely follow all the latest news. Their knowledge of online betting, combined with their understanding of the NFL, makes them a reliable source of American football predictions.

Once again, the Kansas City Chiefs top Super Bowl odds and Patrick Mahomes will be hoping to lift the Vince Lombardi Trophy at the end of last season.

While the Chiefs are deserving of their status as NFL season preview favourites, there are plenty of teams who will fancy their chances at a deep postseason run.

Look out for the Eagles, Bills, Bengals, Niners and others in the opening weeks as they look to prove they can topple the dynastic Chiefs.

Elsewhere, Mahomes is again a popular NFL betting UK pick for MVP. Other contenders include Lamar Jackson, Jalen Hurts, Josh Allen and Joe Burrow.

Our team will keep an eye on NFL awards betting throughout the season, where odds movement can unlock value.

NFL Predictions Each Week

Running through from Week 1 to the NFL London games and the final hunt for Playoff positioning around Christmas and New Year, 888Sport’s established group of NFL tipsters will be updating this page with weekly tips.

Once the regular year is wrapped up, attention will turn to what should be a fascinating Playoffs. You can follow the latest NFL news from former star cornerback Jason Bell via his exclusive 888sport blog each week.

Expertise is paired with extensive NFL statistics research as we land on our free NFL tips.

Head-to-head records, injury updates and analytics are all considered by our writers before they commit to the wager which you will see on this page. 

This is a must visit page for anyone looking to wager on NFL games during the 2024-25 season – bets are available every week of the season, and 888Sport has an exceptional range of markets to enjoy.


*Credit for all photos in this article belongs to Adobe*

Ben is very much a sports nerd, being obsessed with statistical deep dives and the numbers behind the results and performances.

Top of the agenda are hockey, football, and boxing, but there's always time for some NFL, cricket, Formula One, and a bit of mixed martial arts.